OBJECTIVE: To evaluate shear bond strength of 2 different fluoride-releasing sealants and their adhesive remnant index (ARI). STUDY DESIGN: A total of 105 extracted human maxillary premolars were divided into 3 groups of 35. Slot brackets (0.018-inch) were bonded to buccal surfaces of teeth using Pro Seal, Opal Seal, and, as a control group, Transbond XT. Transbond XT Composite was used only as an adhesive material. All samples were subjected to thermocycling for 5,000 cycles in water baths between 5°C and 55°C. Subsequently, the shear bond strengths of specimens were determined under loads vertically at 0.5 mm/min crosshead speed until rupture occurred. After the shear bond strength test, specimens were examined with a stereomicroscope at ×20 magnification and grouped according to ARI analysis. Statistical analyses were performed using one-way ANOVA analysis of variance for shear bond strength data and Kruskal-Wallis and Mann-Whitney U tests for ARI analysis. RESULTS: There was no significant difference between all the groups (p>0.05) with regard to shear bond strength. According to ARI analyses, the control group was statistically different from both the Pro Seal and Opal Seal groups (p<0.05). However, there was no significant difference between the Pro Seal and Opal Seal groups for ARI analyses. CONCLUSION: The results of this study showed that the potential of caries and white spot lesions during orthodontic treatment can be decreased by using new fluoride-releasing sealants. However, this is an in vitro study and these results should be supported with clinical studies. © Science Printers and Publishers, Inc.