OBJECTIVE: To explore the influence of different anesthesia methods on the prognosis of elderly patients with hip fracture and reduce the occurrence of adverse reactions. Hip fracture occurs frequently in the elderly, but the prognosis is not ideal. STUDY DESIGN: Data of elderly patients with hip fracture who underwent surgical treatment in the orthopedics department of our hospital from January 2015 to January 2018 were collected. A total of 182 patients were divided into general anesthesia group (58 cases), lumbar plexus+sciatic nerve block anesthesia group (63 cases), and intra-vertebral anesthesia group (61 cases) according to the anesthesia method. The incidence of postoperative complications was compared among the 3 groups, and the degree of postoperative pain, early time out of bed, and length of hospital stay were evaluated. RESULTS: Respiratory complications and delirium in the general anesthesia group were higher than those in the other 2 groups, and the early getting out of bed time was significantly later than that in the other 2 groups. Visual analogue scale (VAS) score of pain was the highest in the general anesthesia group and higher in the intraspinal anesthesia group than in the lumbar plexus+sciatic nerve block anesthesia group. There wasno statistical significance in the comparison of other postoperative adverse reactions. CONCLUSION: In the operation of senile hip fracture, the 3 groups all have their own advantages and disadvantages. Lumbar plexus+sciatic nerve block is more advantageous than general anesthesia and intraspinal anesthesia, and postoperative complications and adverse reactions are lower and postoperative outcomes are better. (Anal Quant Cytopathol Histpathol 2021;43: 939–944) © Science Printers and Publishers, Inc.