OBJECTIVE: To study the clinical effects of meditation training on hallucinatory paranoia in patients with chronic schizophrenia. STUDY DESIGN: A total of 120 patients with chronic schizophrenia and illusory delusional symptoms were chosen and randomly divided into observation group and control group. The observation group was treated with meditation under the same conditions as the conventional treatment. The control group maintained only the original routine treatment unchanged. After 8 months of treatment the psychiatric symptoms were assessed with the negative symptom scales (Positive and Negative Symptoms Scale [PANSS]), the psychotic positive symptoms were assessed with the positive symptom scales (Scales for the Assessment of Positive Symptoms [SAPS]), and SF-36 quality of life scale was used to evaluate the health condition. We also used the five-factor mindfulness scale to understand changes in mindfulness meditation. RESULTS: After treatment the symptoms of both groups were improved, and the patients in the observation group were more stable, with less psychotic positive symptoms, higher quality of life, and stronger mindfulness meditation. CONCLUSION: As a result, we believe meditation training can effectively alleviate the hallucinatory paranoia of patients with chronic schizophrenia. © Science Printers and Publishers, Inc.